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In very rarely reported side effects, Zoloft can cause hallucinations, partial or full body seizures, skin rashes and in around 22% of patients- night sweats (Brim, 2022). Over time, more mild side effects of Zoloft fade away as the body adjusts to the new medication. There is a strong dose relationship with these side effects, often increasing in severity as the dosage increases. Many of the side effects will be immediately apparent within the first week of taking the medication, with side effects such as nausea and fatigue/ drowsiness appearing early on in treatment. Zoloft is contraindicated in pregnant women as it has been linked to increased risk of birth defects (Anderson et al., 2020).

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In men, Zoloft can cause erectile dysfunction and difficulty in ejaculation, while in women it can limit or cause difficulty in achieving an orgasm (Rosen Marin, 2003). Specific sexual dysfunctions in men and women.Including insomnia, Zoloft also has a number of other reported side effects by the Mayo Clinic (2022), such as: Many patients also report a very strong positive effect of physical activity on getting better, deeper sleep as well as battling the root cause of the initial disorder that requires treatment with Zoloft. You should avoid caffeinated drinks, entirely or limit them only to the morning, as caffeine has a 12-hour half-life (Schutte-Rodin et al., 2008). Most patients who are suffering from Insomnia find that taking Zoloft in the morning helps to reduce the drug’s effect on sleep. Taking Zoloft in the morning or evening will depend on if the drug makes you feel drowsy or not (Wang et al., 2019). In order to limit the effect Zoloft has on your sleep patterns, you should take your dose of Zoloft at the same time each day, either in the morning or evening. Other studies have directly implicated antidepressants in patients with induced insomnia, due to the effect the drug has with sleep physiology (Wilson, and Argyropoulos, 2005). Transient insomnia (lasting days or even weeks) as well as chronic insomnia (lasting years) have both been linked to antidepressant use such as Zoloft in recent studies (Holshoe, 2009).

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Insomnia is the most common sleep disorder in America, with an estimated 70% of all Americans suffering from this condition each year. When is the Best Time to Take Zoloft for Sleep? For some patients, Zoloft-related insomnia is temporary, while for others it can be ongoing and require further assessment and treatment (Wilson, and Argyropoulos 2005). This results in poor overall recovery and feelings of chronic fatigue (Lewis, et al., 2019). Various clinical studies have also shown that SSRIs like Zoloft increase the amount of time it takes to fall asleep, leading to interrupted sleep patterns and reduced time spent in rapid eye movement (REM) sleep. These changes in brain chemistry are hypothesised to be the cause of antidepressant induced insomnia in some patients. Studies by Wilson & colleagues in 2014, demonstrate in animal models the effect Zoloft can have in changing the levels of other neurotransmitters in the brain, such as the reuptake of serotonin. Many patients who are prescribed Zoloft and other related drug compounds of this class reported reduced symptoms of depression but worsening insomnia. Unlike some other therapies for mental health disorders, Zoloft is not a sedative, it is a SSRI, which does not cause drowsiness, however it does have an effect on sleep, with many patients reporting fatigue as a common side effect (Wichniak, et al., 2017). Does Zoloft Cause Insomnia?Īccording to British National Formula, the most commonly reported side effects are headache, nausea, diarrhoea, weight loss, insomnia, and sexual dysfunction. Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants, but it is not without its side effects (Turner, and Phelon, 2022 Ahmadpanah et al., 2019). It is believed that this rebalancing is the main action by which Zoloft helps people with anxiety, depression, and other disorders. It is this blocking of certain reuptake pathways, which helps to rebalance chemicals in the brain. SSRIs are thought to work by preventing the reuptake of serotonin by nerves, leading to an increase in serotonin concentrations within the nerve synapse (space between two nerves) (Yoham and Casadesus, 2022). Zoloft belongs to a group of medicines called Selective Serotonin Reuptake Inhibitors (SSRIs). Zoloft, with the generic name of Sertraline, is a commonly prescribed medication to treat depression, anxiety disorders, obsessive compulsive disorders and other emotionally induced stress disorders.












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